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diagnosis differential liver lfts rheumatology transaminitis alcoholic causes classification dili druginduced hepatocellular management patterns saag vasculitides
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
, HBV, HCV, HEV, ... disease, Hepatic ischaemia ... disorder (e.g. ascites ... ), Chronic hepatitis ... #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver Injury ... normal - Infection (EBV ... 5-10x normal - Chronic ... Patterns #Liver #Injury ... #hepatology #LFTs
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... • Vascular: Ischemic ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... , HBV, HCV, HEV, ... > 2 • NASH, Chronic ... : > 3 • Chronic ... #hepatology
Causes of Ascites Normal Peritoneum Portal hypertension (SAAG > 1.1 g/dL) 1. Hepatic congestionl
- Alcoholic hepatitis ... peritonitis - HIV-associated ... Mediterranean fever ... - Vasculitis ... #differential #hepatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
: • Purpura, ischemic ... Eosinophilia, asthma, chronic ... Coronary arteries - Fever ... : • Fevers • ... • HBV HCV •
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... - Management Algorithm ... blood, urine and ascites ... - Acute kidney injury ... #hepatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
: • Purpura, ischemic ... : • Fevers • Fatigue ... HTN • Check: HBV ... Eosinophilia, asthma, chronic ... - interstitial keratitis
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