10 results
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
, HBV, HCV, HEV, ... Hepatic ischaemia ... disorder (e.g. ascites ... ), Chronic hepatitis ... #Algorithm #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm

• Who to treat: Essentially treat the pts with
Chronic Hepatitis ... HAV immunity; Liver ... Chronic Hepatitis ... #HepatitisB #HBV ... Management #Treatment #Hepatology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... Injury Transaminase ... normal - Infection (EBV ... 5-10x normal - Chronic ... #Injury #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... : HAV, HBV, HCV, ... HEV, EBV, HSV, ... #injury #hepatitis ... #hepatology
Ascites - Differential Diagnosis
Chronic liver disease (cirrhosis or chronic hepatitis) - 80%
Underlying malignancy - 10%
Congestive heart
Diagnosis Chronic ... liver disease ( ... hepatitis) - 80% ... Fitz-Hugh-Curtis syndrome), HIV-related ... Differential #Diagnosis #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Injuryliver ... CMV, HSV, VZV ... • Vascular: Ischemic ... #Diagnosis #hepatology ... #algorithm #Transaminitis
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Injury - Differential ... , CMV, HSV • Toxic ... #Injury #Differential ... Causes #Acute #algorithm ... #hepatology
Causes of Ascites
Normal Peritoneum
Portal hypertension (SAAG > 1.1 g/dL)
  1. Hepatic congestionl
Liver disease ... - Alcoholic hepatitis ... peritonitis - HIV-associated ... Mediterranean fever - Vasculitis ... #differential #hepatology
Alcoholic Hepatitis - Management Algorithm
Assess Eligibility for Treatment:
 - Maddrey Discriminant Function ≥ (or possibly MELD
- Acute kidney injury ... diseases including HBV ... HCV, DILI, HCC, ... HIV, TB - Multiorgan ... #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
serologies, HCV ... serologies, HCV ... > 2 • NASH, Chronic ... : > 3 • Chronic ... #differential #Hepatology