14 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Hepatitis > ... - Acute Viral Hepatitis ... , Toxic Hepatitis ... Hepatitis AST ... #hepatology #LFTs
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
, HBV, HCV, HEV, ... EBV, CMV), Alcohol-related ... ascites), Chronic hepatitis ... • Autoimmune hepatitis ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
• Infectious: Hepatitis ... NAFLD, Autoimmune hepatitis ... Hepatitis, TPN ... Sepsis, Viral Hepatitis ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... #algorithm #Transaminitis ... #LFTs #hepatitis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
, HBV, HCV, HEV, ... Autoimmune: Autoimmune hepatitis ... Chronic viral hepatitis ... #hepatitis #differential ... #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Differential Diagnosis Algorithm ... Drugs/Toxins • Ischemia ... • NAFLD • Alcohol ... hepatitis • Drugs ... Others #LFTs #Hepatology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
• Early acute hepatitis ... • Ischemic hepatitis ... hepatitis (ALT-to-LDH ... 1.5) from viral hepatitis ... fever) • Drugs (alcohol
Alcoholic Hepatitis - Management Algorithm
Assess Eligibility for Treatment:
 - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... - Acute kidney injury ... diseases including HBV ... #Hepatitis #Management ... #Algorithm #hepatology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Acute Kidney Injury ... - AKI Workup Algorithm ... cryoglobulins, hepatitis ... serology, HIV serology ... #AKI #Workup #Algorithm
Sensorineural Hearing Loss - Differential Diagnosis Algorithm

Asymmetric Sensorineural Hearing Loss: 
 • Neoplastic (Vestibular Schwannoma)
 •
Differential Diagnosis Algorithm ... Toxoplasmosis, HIV ... , Syphilis, Hepatitis ... Teratogenic drugs, Alcohol ... Cardiovascular Ischemia