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diagnosis injury causes lfts transaminitis saag albumin alcoholic dili druginduced gradient hepatocellular hypertension management patterns portal serum tests
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
, HBV, HCV, HEV, ... Hepatic ischaemia ... dechallenge • Acute ... disorder (e.g. ascites ... #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... 20x normal - Acute ... normal - Infection (EBV ... #Injury #hepatology ... transaminitis #differential
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Hepatopathy • Acute ... Viral Hepatitis ... injury) • Ischemic ... #Diagnosis #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... , Acute biliary ... #Injury #Differential ... #algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... , HBV, HCV, HEV, ... Tests of synthetic function ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... • Vascular: Ischemic ... #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Causes of Ascites Normal Peritoneum Portal hypertension (SAAG > 1.1 g/dL) 1. Hepatic congestionl
- Alcoholic hepatitis ... fibrosis - Acute ... fatty liver of ... Causes #diagnosis #differential ... #hepatology #SAAG
Serum Ascites Albumin Gradient (SAAG) - Differential Diagnosis High albumin gradient (>1.1 g/dl): - Cirrhosis - Alcoholic
- Alcoholic hepatitis ... - Massive liver ... Veno-occlusive disease - Acute ... associated with bowel ischemia ... #Diagnosis #hepatology
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
Hypertension - Differential ... hepatic synthetic function ... • Cirrhosis/acute ... hepatitis • Infiltrative ... Diagnosis #causes #hepatology
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... - Management Algorithm ... Maddrey Discriminant Function ... blood, urine and ascites ... #hepatology
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