15 results
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
for alternative causes ... , HBV, HCV, HEV, ... EBV, CMV), Alcohol-related ... Hepatic ischaemia ... #hepatology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... normal - Infection (EBV ... /CMV), Alcoholic ... #Patterns #Liver ... #Injury #hepatology
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
Hepatitis (AH) ... factors • Possible ischemic ... ) or metabolic liver ... #Hepatitis #AH ... #hepatology #criteria
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
Trauma: Shock liver ... • Autoimmune hepatitis ... See Updated Schema ... Differential #Diagnosis #causes ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... : Alcohol, Medication ... Medication, Pregnancy, Alcoholic ... #Acute #algorithm ... #hepatology
Alcoholic Hepatitis - Management Algorithm
1. Severity assessed not only by MDF (>32) but also by MELD
Alcoholic Hepatitis ... - Management Algorithm ... survival in severe AH ... can be bridge to Liver ... #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Drugs/Toxins • Ischemia ... hepatitis • Drugs ... Others #LFTs #Hepatology ... #Causes
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Drugs (MDMA), Alcohol ... • Vascular: Ischemic ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Differential Diagnosis Algorithm ... Non-Malignant • Fatty Liver ... Inflammatory • Alcoholic ... Differential #Diagnosis #Algorithm ... #Causes #Hepatology
Causes of Ascites
Normal Peritoneum
Portal hypertension (SAAG > 1.1 g/dL)
  1. Hepatic congestionl
Causes of Ascites ... Liver disease ... Cirrhosis - Alcoholic ... hepatitis ... #differential #hepatology