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diagnosis differential injury causes elevated abnormal calling chemistry consultation drug druginduced elevation function functiontest giconsult hepatocellular idiosyncratic induced interpretation liverenzymes
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... (>1000): • DILI ... injury) • Ischemic ... Differential #Diagnosis #hepatology ... #transaminitis
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... > 50x normal - Ischemic ... #Patterns #Liver ... #Injury #hepatology ... #LFTs #transaminitis
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
(LFTs) Elevation ... abnormality vs bone Bili ... - Direct (Obstructive ... #Elevation #Transaminitis ... #diagnosis #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... or symptoms of liver ... Diagnosis #Management #gastroenterology ... #algorithm #gastroenterology ... #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Transaminases / Transaminitis ... Trauma: Shock liver ... • Iatrogenic: DILI ... See Updated Schema ... Diagnosis #causes #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... disease, Hepatic ischaemia ... • Autoimmune hepatitis ... #Diagnosis #Algorithm ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... • Vascular: Ischemic ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... for Transaminitis ... Drugs, Viral, Ischemia ... Burak @kwburak #LFTs ... #hepatology #LiverFunctionTests
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... life: 1 week • Direct ... #differential #Hepatology ... #transaminitis ... #LFTs #RValue #interpretation
The Liver Consult Primer - Guide to calling a consult HPI: - Start with reason for consult
- Vitals - LFTs ... plt, INR, GTT, indirect ... bili/ current MELD ... Calling #Referral #Hepatology ... #Gastroenterology
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