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algorithm causes anemia hepatology management workup classification syndrome transaminitis abnormal disease hepatitis bleeding coagulation comparison dermatology injury laboratory oncology systemic
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... 2-5x normal - Hemolysis ... #LFTs #transaminitis ... #differential # ... diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... for Hemolysis - ... lymphoproliferative disorders ... Extravascular #Causes #differential ... #diagnosis #hematology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Differential Diagnosis ... injury) • Ischemic ... #Differential # ... Diagnosis #hepatology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Splenomegaly - Differential ... Diagnosis Algorithm ... Myeloproliferative disorders ... Serum Sickness Hemolytic ... #Causes #Hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Approach to Anemia - Differential ... Diagnosis Framework ... aciduria, Drugs (e.g ... Non-megaloblastic: Liver ... #Diagnosis #hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Diagnosis Algorithm ... Sequestration Disordered ... Rare • Drugs (e.g ... Iatrogenic) • Liver ... #Causes #Hematology
Anemia - Underproduction Diagnostic Algorithm - Iron deficiency anemia - Anemia of chronic inflammation - Anemia
Underproduction Diagnostic ... Probable bone marrow disorder ... - TSH, LFTs, ... Underproduction #Algorithm #hematology ... #diagnosis #differential
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
Neutrophils - Differential ... Diagnosis Algorithm ... Solid Tumour (e.g ... • Metabolic disorders ... #Causes #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential ... Diagnosis and Workup ... gastric bypass), LFT ... (liver disease) ... #Workup #hematology
Pancytopenia - Differential Diagnosis Algorithm • 12-13 g/dL, • ANC < 1800/uL, • platelet < 150,000/uL Initial
Diagnosis Algorithm ... reticulocyte count, LFTs ... Diagnosis: • ... ↑ Destruction (hemolysis ... #hematology #workup
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