27 results
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... Cell Disease Vaso-occlusive ... : ischemic pain ... #diagnosis #causes ... #hematology
Chest Pain - Differential Diagnosis Algorithm
Cardiovascular Causes:
 - Outflow Obstruction
     • Aortic
Chest Pain - Differential ... Aortic Stenosis - Ischemic ... Angina - Non-lschemic ... Embolism (chest pain ... • Trauma - Neurologic
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... autoantibodies that will cause ... ischemia and/or ... cyclophosphamide • Ischemic ... #rheumatology #
Causes of Dizziness - Vertigo - Differential Diagnosis Algorithm
True Vertigo - Illusion of Rotary Movement
Peripheral Vestibular
Causes of Dizziness ... • Meniere's Disease ... Media • Temporal Bone ... • Transient Ischemic ... Diagnosis #Algorithm #Causes
Leg Pain - Differential Diagnosis Framework

Bone/Joint Causes of Leg Pain:
 • Fracture
 • Arthritis
 • Gout/pseudogout
Diagnosis Framework Bone ... Legg-Calve-Perthes disease ... • PAD • Limb ischemia ... • Acute limb ischemia ... extremity #msk #physicalexam
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Drugs/Toxins • Ischemia ... • Cholestatic disease ... Infiltrative • Cirrhosis ... Others #LFTs #Hepatology ... Diagnosis #Algorithm #Causes
Vascular Joint Pain - Differential Diagnosis Algorithm 
 - Constant Pain (Ischemia)
 - Acute Onset
 -
(Ischemia) - ... Peripheral Vascular Disease ... fractured long bone ... • Dislocated Bone ... #Orthopedics #Causes
Causes of Nausea and Vomiting - Differential Diagnosis Framework

Chemoreceptor Trigger Zone/Area Postrema:
 • Drugs:
	- Chemo agents
	-
Causes of Nausea ... Chemoreceptor Trigger Zone ... - Addison’s disease ... • Stress • Pain ... • Mesenteric ischemia
Sickle Cell Disease - Pathophysiology of disease and complications 

Due to the deformed shape, HbS induces
Sickle Cell Disease ... Pathophysiology of disease ... organs leading to ischemia ... , necrosis and pain ... Complications #Hematology
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
FLAGS - In all cases ... Malignancy - Night pain ... splenomegaly, abnormal neurology ... , back pain Haematology ... Rheumatology