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anemia management causes classification oncology algorithm blood hemolysis hodgkins joint lymphoma product agglutinin apml atlas basophilia basophils calculation clinical cold
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... , Acute hemolysis ... , Vasculitides, ... IBD, Celiac disease ... #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Other: Transfusion reaction ... - Transfusion reaction ... Extravascular #Causes #differential ... #diagnosis #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... - APLS • Acute ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Associated with Joint Pain ... parvovirus B19 infection ... Sarcoidosis #dermatology ... #rashes #differential ... #diagnosis #rheumatology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Diagnosis Algorithm ... cardiac valve, vasculitis ... inclusions - If infection ... #workup #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... Causes: • Liver disease ... drug induced • Infections ... • Transfusion reactions ... classification #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... AIHA, Transfusion reactions ... Internal (RBC) - Infections ... Diagnosis #hematology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Basophilia - Differential ... Diagnosis Framework ... Colitis and Crohn’s Disease ... #Diagnosis #causes ... #hematology #basophils
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
burning sensation or pain ... reticularis Differential ... Diagnosis: Vasculitis ... Polyangiitis #GPA #dermatology ... #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Diagnosis: • hemolytic ... younger pts) Differential ... chills, flank pain ... #hematology #diagnosis
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