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Jaundice - Pathophysiology and Causes

- Amy Chung, MD, MSc @AmyChung 

#Jaundice #Pathophysiology #Differential #Unconjugated #Causes #Diagnosis
Jaundice - Pathophysiology ... and Causes - ... #Pathophysiology ... #Differential # ... Unconjugated #Causes
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Classification of Jaundice ... reactions, hematoma, pulmonary ... miscellaneous causes ... #unconjugated #differential ... #causes
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... Normal Acid-Base: Low ... #Hypokalemia #Differential ... Diagnosis #Algorithm #causes ... #nephrology
Jaundice - Differential Diagnosis Algorithm
Pre-Hepatic - Unconjugated Hyperbilirubinemia
Increased Production
 • Hemolysis
 • Ineffective Erythropoiesis
 • Hematoma
Decreased
Jaundice - Differential ... • Gilbert's Syndrome ... Crigler-Najjar Syndromes ... #Differential # ... Diagnosis #Algorithm #Causes
Causes of Hypokalemia - Differential Diagnosis Algorithm
Increased Loss 
 - Increased GI Loss
 - Increased Urinary
Causes of Hypokalemia ... - Differential ... - Refeeding Syndrome ... #potassium #low ... #pathophysiology
Causes of Hyponatremia - Differential Diagnosis Algorithm
Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
Causes of Hyponatremia ... - Differential ... Diagnosis Algorithm Syndrome ... • Drugs • Pulmonary ... #Differential #
Causes of Hyponatremia - Differential Diagnosis Algorithm
Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
Causes of Hyponatremia ... - Differential ... Diagnosis Algorithm Syndrome ... • Drugs • Pulmonary ... #Differential #
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Metabolic Alkalosis - Differential ... , NGT suction, Low ... Metabolic #Alkalosis #Differential ... Diagnosis #Algorithm #Nephrology ... #Causes
Hypoxemic Respiratory Failure - Differential Diagnosis Framework
DECREASED INSPIRED OXYGEN
 • Low PATM Can decrease first part
Respiratory Failure - Differential ... INSPIRED OXYGEN • Low ... respiratory drive due to neurologic ... obesity-hypoventilation syndrome ... hepatopulmonary syndrome
Hypoxia and Hypoxemia - Overview
Hypoxia - insufficient oxygen delivered to tissues to meet demands
Hypoxemia - low
demands Hypoxemia - low ... Hypoxemia #summary #pulmonary ... #differential # ... diagnosis #causes ... #pathophysiology