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diagnosis hematology oncology differential mds myelodysplastic thrombocytosis alcoholic aplastic bacilliformis bartonella cirrhosis common cvid essential et fever hepatitis hepatopulmonary hps
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... : • Acute or Chronic ... effect following treatment ... Iron deficiency anemia ... #Causes #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... cytopenias (usually anemia ... only curative treatment ... #treatment #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Differential Diagnosis Algorithm ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... • Infections: Chronic
Oroya Fever Hematologic disease caused by Bartonella bacilliformis Restricted to the Andes highlands of Peru & Ecuador B. bacilliformis:
Hematologic disease caused ... severe hemolytic anemia ... , jaundice ​• Neuro ... TREATMENT: ​• Acute ... Fever #diagnosis #management
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... and petechiae Causes ... Treatment: ... #oncology #hematology ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Out Secondary Causes ... Marrow Failure • Chronic ... factor (GCSF) treatments ... marrow studies Treatment ... #diagnosis #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Autoimmunity • Chronic ... autoimmune hemolytic anemia ... DDX - Other causes ... : • Nephrotic syndrome ... Malignancies • Chronic
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis - Management ... Algorithm Assess ... exclude other causes ... of jaundice - ... #Algorithm #hepatology
Hepatopulmonary Syndrome - Illness Script HPS is a pulmonary disorder of chronic liver disease characterized by a
pulmonary disorder of chronic ... triad of: 1) chronic ... arteriovenous shunting causes ... of cirrhosis: jaundice ... cirrhosis #diagnosis #hepatology
Essential Thrombocythemia (ET) ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
(ET) ET is a chronic ... Most cases are related ... • Treatment algorithms ... #diagnosis #management ... #hematology
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