17 results
diagnosis hematology differential oncology algorithm management mds myelodysplastic platelets acidosis aplastic cancer chronic cirrhosis classification cll elevation gap globulin hepatopulmonary
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... Myelodysplastic syndrome ... Chronic myeloid leukemia ... #hematology #secondary
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Chronic Myelogenous Leukemia ... effect following treatment ... Iron deficiency anemia ... #Hematology
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Thrombocytosis - ... Reactive: • Anemia ... Chronic Myeloid Leukemia ... Differential #Diagnosis #causes ... #Platelets #hematology
Hyperviscosity Syndrome - Causes and Treatment - Waldenstrom macroglobulinemia (most common) / Plasmapheresis - Multiple
Hyperviscosity Syndrome ... - Causes and Treatment ... Plasmapheresis - Leukemia ... Hydroxyurea - Leukemia ... Hydroxyurea - Thrombocytosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Approach to Thrombocytosis ... → Refer to hematology ... hemolysis, deficiency anemia ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... cytopenias (usually anemia ... transformation to acute leukemia ... #hematology #oncology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic Anemia ... Leukemia, Tumour ... Non-lmmune: • HELLP Syndrome ... #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... basophilia, and thrombocytosis ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... and petechiae Causes ... virus (EBV) • Leukemia ... Treatment: ... #oncology #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... microglobulin Treatment ... • Richter’s Syndrome ... • Sezary syndrome ... workup #oncology #hematology
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