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Approach to the neonate with jaundice

#Diagnosis #Peds #Pediatrics #Neonatal #Jaundice #Algorithm #Differential #Workup

** GrepMed Recommended Text:
Approach to the neonate ... with jaundice ... Peds #Pediatrics #Neonatal ... #Jaundice #Algorithm
Clinical Examination for Liver and Biliary Diseases
1) Hands: Clubbing, Dupuytren's contracture, Leuconychia, Bruising, Flapping tremor (hepatic
Examination for Liver ... and Biliary Diseases ... erythema 2) Face: Jaundice ... Xanthelasma and jaundiced ... Bruising, Edema #biliary
Approach to Neonatal Jaundice

Causes of pathologic hyperbilirubinemia can be classified as due to (1) increased bilirubin
Approach to Neonatal ... Jaundice Causes ... Peds #Pediatrics #Neonatal ... #Jaundice #Algorithm
Jaundice - Differential Diagnosis Algorithm
Pre-Hepatic - Unconjugated Hyperbilirubinemia
Increased Production
 • Hemolysis
 • Ineffective Erythropoiesis
 • Hematoma
Decreased
Jaundice - Differential ... on Ultrasound Biliary ... Gallstones • Biliary ... Cholangitis #Jaundice
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
Primary Biliary ... discomfort Signs: Jaundice ... Liver biopsy findings ... #PBC #Primary #Biliary
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Classification of Jaundice ... Dysfunction - Biliary ... certain drugs, biliary ... postoperative jaundice ... neoplasms #Jaundice
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
of Severe Acute Liver ... hepatitis - Acute biliary ... - Drug-Induced liver ... Hemochromatosis - Primary biliary
Diseases of the Biliary Tract
Asymptomatic gallstones - Asymptomatic
Symptomatic gallstones - Biliary pain
Cholesterolosis of gallbladder - Usually
Diseases of the Biliary ... Symptomatic gallstones - Biliary ... cholecystitis - Biliary ... Asymptomatic or biliary ... pain, jaundice,
The Liver Consult Primer - Guide to calling a consult
HPI:
 - Start with reason for consult
The Liver Consult ... Important findings: jaundice ... Focus on prior Liver ... MELD - Chronic liver ... US - Prior liver
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Disease: Primary Biliary