20 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
- infiltrates (anemia ... • Age: 60-80 Clonal ... CLL Symptoms: • ... Leukemia (CLL) ... #Hematology #Oncology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
Leukemia (CLL) ... cytometry → >500/uL clonal ... marrow failure with anemia ... uw_IMresidency #CLL ... #Leukemia #oncology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... with no early symptoms ... • Neutropenia, anemia ... leukemia #CLL ... #workup #oncology
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia
Clinical
 - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
Large Granular Lymphocytic ... Neutropenia (85%), anemia ... as pancytopenic/ill ... mature cytotoxic T-cell ... LargeGranular #Lymphocytic
Multiple Myeloma Diagnosis and Management Summary
Clinical Signs:
 • hyperCalcemia 28% (bone demineralization)
 • Renal disease 48%
hypercalcemia) • Anemia ... ) Diagnosis - Clonal ... • >60% plasma clonal ... cell in bone marrow ... Diagnosis #Management #oncology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Aplastic Anemia ... Script Signs and symptoms ... • Symptomatic anemia ... Consider stem cell ... to MDS or acute leukemia
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
cytopenias (usually anemia ... transformation to acute leukemia ... Allogeneic stem cell ... treatment #hematology #oncology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Rich, Lymphocyte ... pattern of spread, B symptoms ... common - T Cell ... ~10% - B-Cell ... Treated Like Acute Leukemias
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
40 ml/min A - Anemia ... 1 or more: • Clonal ... marrow plasma cell ... diseases, CML, ... diagnosis #hematology #oncology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
- B symptoms ... involved) • No leukemic ... Nodal disease: B symptoms ... Diagnosis of B-Symptoms ... NonHodgkins #comparison #oncology