19 results
diagnosis hematology management differential algorithm aplastic chronic classification hodgkins lymphoma mds mgus monoclonal myelodysplastic syndrome treatment workup acute cancer comparison
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
- infiltrates (anemia ... • Age: 60-80 Clonal ... CLL Symptoms: • ... Leukemia (CLL) ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... CLL Labs: 1. ... • Neutropenia, anemia ... leukemia #CLL ... #workup #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) ... cytometry → >500/uL clonal ... Transformation to large cell ... uw_IMresidency #CLL ... #Leukemia #oncology
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia Clinical - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
Lymphocytic Leukemia ... Neutropenia (85%), anemia ... as pancytopenic/ill ... mature cytotoxic T-cell ... LargeGranular #Lymphocytic
Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
hypercalcemia) • Anemia ... ) Diagnosis - Clonal ... marrow plasma cells ... cell in bone marrow ... Diagnosis #Management #oncology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Rich, Lymphocyte ... pattern of spread, B symptoms ... common - T Cell ... ~10% - B-Cell ... Treated Like Acute Leukemias
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
typically of B-cell ... involved) • No leukemic ... Reed Sternberg cell ... based on: - Cell ... type (B cell, T
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
= funny-shaped cells ... cytopenias (usually anemia ... transformation to acute leukemia ... Allogeneic stem cell ... treatment #hematology #oncology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Script Signs and symptoms ... • Symptomatic anemia ... Consider stem cell ... to MDS or acute leukemia
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... low red blood cell ... Chronic Myelogenous Leukemia ... Leukemia • Idiopathic ... diagnosis #hematology #oncology
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