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hematology management differential syndrome algorithm aplastic chronic classification hodgkins lymphoma mds mgus monoclonal myelodysplastic treatment workup acute cancer cell comparison
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
- infiltrates (anemia ... • Age: 60-80 Clonal ... CLL Symptoms: • ... Leukemia (CLL) ... #Diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) ... minimal tumor burden Diagnosis ... cytometry → >500/uL clonal ... uw_IMresidency #CLL ... #Leukemia #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... • Neutropenia, anemia ... leukemia #CLL ... #Leukemia #diagnosis ... #workup #oncology
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia Clinical - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
Large Granular Lymphocytic ... Neutropenia (85%), anemia ... as pancytopenic/ill ... LargeGranular #Lymphocytic ... #pathology #diagnosis
Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
hypercalcemia) • Anemia ... - Clonal bone marrow ... • >60% plasma clonal ... cell in bone marrow ... #Management #oncology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Script Signs and symptoms ... Diagnosis: • Pancytopenia ... Consider stem cell ... to MDS or acute leukemia ... #diagnosis #management
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Syndrome (MD) - Diagnosis ... cytopenias (usually anemia ... transformation to acute leukemia ... Allogeneic stem cell ... treatment #hematology #oncology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
- Differential Diagnosis ... pattern of spread, B symptoms ... ~10% - B-Cell ... Treated Like Acute Leukemias ... pathophysiology #Hematology #Diagnosis
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
- B symptoms ... involved) • No leukemic ... Differential Diagnosis ... NonHodgkins #comparison #oncology ... #diagnosis #differential
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
40 ml/min A - Anemia ... 1 or more: • Clonal ... diseases, CML, ... Gammopathies #MGUS #diagnosis ... #hematology #oncology
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