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Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features • RA affects 1% of population, women >
Pathogenesis and Joint ... poly-articular joint ... Joint involvement ... space decr joint ... RheumatoidArthritis #RA #pathophysiology
Rheumatoid arthritis (RA): X-ray features • Soft tissue swelling (best seen by comparing left & right
together) • Joint ... closer to the joints ... ) • Joint Subluxations ... (Joint deformities ... Radiology #Clinical #Pathophysiology
Reactive Arthritis • Inflammation of joints (commonly large joints) - Asymmetric Oligoarthritis: Joint
Inflammation of joints ... commonly large joints ... Oligoarthritis: Joint ... pain in a few joints ... ReactiveArthritis #pathophysiology
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
and Degenerative joint ... Inflammatory Joint ... Swelling stimulates joint ... • Moving the joint ... JointPain #Diagnosis #pathophysiology
Rachitic Rosary of Rickets on Physical Exam Bead-like prominences of bone are seen at the costochondral joints.
costochondral joints ... costochondral joint ... Rosary #Rickets #PhysicalExam
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 Osteoarthritis (OA): Clinical findings • Stimulation of joint nociceptors in subchondral bone -> Pain with loading
Stimulation of joint ... loading / use of joint ... Disruption of normal joint ... movement of the joint ... Osteoarthritis #OA #pathophysiology
Gout: Pathogenesis and Clinical Findings - Conditions of rapid cell turnover: hemolysis, psoriasis, lymphoproliferative disorders -
easily leaks into joints ... in a peripheral joint ... Neutrophils enter joint ... degradative enzymes into joint ... Hyperuricemia #Pathophysiology
Rheumatoid Arthritis Summary Overview: chronic, inflammatory symmetric polyarthritis involving small joints of hands/feet, knees, shoulders Signs & Symptoms:
involving small joints ... inflammatory) • joint ... • synovitis; joint ... tenderness • joint ... narrowing) • Ultrasound
Patellofemoral Syndrome - Pathogenesis and clinical findings • Anterior Knee Pain with possible symptoms of 'catching'
patellofemoral joint ... patellofemoral joint ... patellofemoral joint ... Patellofemoral #Syndrome #pathophysiology
Pseudogout: pathogenesis and clinical findings - Idiopathic (vast majority of cases) -> Mechanism unknown - Familial
crystals from joints ... high-resolution ultrasound ... warm, swollen joint ... sclerosis & cysts, joint ... Signs #Symptoms #Pathophysiology
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