73 results
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANA (Antinuclear ... Anti-La/SSB • ... Jcortesizaguirr #ANA #Antinuclear
Antinuclear Antibody Testing - Nuclear Patterns
Homogeneous pattern: 
 • SLE, SSc, AIH, JIA
 • dsDNA, chromatin,
Antinuclear Antibody ... 60 (Ro60), SSB (La ... ARUPLabs #ANA #Antinuclear
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
Antinuclear Antibody ... 60 (Ro60), SSB (La ... ARUPLabs #ANA #Antinuclear
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Anti-Ro/SSA & Anti-La ... primary) • Anti-La ... ab • RF • Antinuclear
Differentiating PAH from PVH - Echocardiography
Pulmonary Artery Hypertension (PAH):
 • RV size - Enlarged
 • LA
- Enlarged • LA ... - Small • RA/LA ... be enlarged • LA ... - Large • RA/LA ... ratio - Normal (LA
Diastolic Dysfunction Grading - Echocardiography
Grade 0  (Normal):
 • E/A >0.8, e’ > 8 cm/s, E/e’
more “Push” from LA ... more “Push” from LA ... Also LA enlargement
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
Discoid Rash A Antinuclear
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
(SSA) and Anti-La ... Anti-Ro (SSA), Anti-La
Antiarrhythmics - Sodium Channel Blockers
Subclasses, Mechanisms, Indications, Side Effects
la - Quinidine, Procainamide
lb - Lidocaine, Mexiletine
Ic -
, Side Effects la
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Kumfer @AnnKumfer #Antinuclear