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diagnosis management differential algorithm clinical hematology hepatology treatment radiology nephrology causes workup cxr msk oncology radiologyassistant collapse criteria lobar pharmacology
Mechanism of Action of Bile Acid Sequestrants Bile Acid Sequestrants → ↓ Hepatic Bile Acid Pool →
Expression → ↑ VLDL ... /Secretion → ↑ LDL ... Production → ↑ LDL ... Receptors → ↑ LDL ... Clearance → ↓ Plasma LDL-C
ACC/AHA Statin Guidelines - 2013 vs 2017 In 2013 the ACC/AHA guidelines drastically changed the way we
the traditional LDL ... group, if the LDL ... alternatively use the LDL ... of the target LDL ... expect a >50% LDL
Abnormal Lipid Profiles - Differential Diagnosis Algorithm Increased Cholesterol and Triglycerides - Genetic Causes
Hypothyroidism Decreased HDL ... Androgens Increased LDL ... ApoB-100 • LDLr ... • Familial LPL
Risk factors for atherosclerosis Modifiable risk factors: - Dyslipidemia (elevated LDL, decreased HDL) - Tobacco smoking -
Dyslipidemia (elevated LDL ... , decreased HDL)
Prescription Fish Oils Prescription fish oils, Lovaza, and Vascepa, are commonly used for treatment of hypertriglyceridemia (TG
of increasing LDL ... without effect on LDL
#Estrogen 25-OH-D3 formation #HDL #LDL #VLDL Y Proliferation and desquamation of #vaginalepithelium In children: delayed epiphyseal fusion #Osteoporosis Atherosclerosis Vaginal infections Tall stature #Progestogen #mammarygland tubes No buildup of uterus
OH-D3 formation #HDL ... #LDL #VLDL Y
Fibrates - Gemfibrozil and Fenofibrate Mechanism: activates PPAR alpha Lipid Effects: - Decrease TG by 30-50% -
50% - Increase HDL ... - Decrease LDL
Lipoprotein Metabolism Enterocytes release absorbed lipids the form of triglyceride-rich chylomicrons. These are acted upon by endothelial
liproprotein (LDL
Stimulation of glycogenolysis, gluconeogenesis Hyperglycemia Accelerated breakdown of VLDL and LDL, stimulation of bile secretion VLDL + Cholesterol Energy metabolism† 02 con- sumption Heat metabolism
breakdown of VLDL ... and LDL, stimulation ... bile secretion VLDL
Xanthoma Striatum Palmare- A 49-year-old man was referred to the metabolic clinic for evaluation of severe
low-density lipoprotein (LDL ... Treatment with LDL
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