7299 results
Mechanism of Action of Bile Acid Sequestrants
Bile Acid Sequestrants → ↓ Hepatic Bile Acid Pool →
Expression → ↑ VLDL ... /Secretion → ↑ LDL ... Production → ↑ LDL ... Receptors → ↑ LDL ... Clearance → ↓ Plasma LDL-C
Abnormal Lipid Profiles - Differential Diagnosis Algorithm

Increased Cholesterol and Triglycerides 
 - Genetic Causes
Hypothyroidism Decreased HDL ... Androgens Increased LDL ... ApoB-100 • LDLr ... • Familial LPL
Xanthoma Striatum Palmare- A 49-year-old man was referred to the metabolic clinic for evaluation of severe
the metabolic clinic ... low-density lipoprotein (LDL ... Treatment with LDL ... #NEJM #clincal #
Risk factors for atherosclerosis

Modifiable risk factors:
 - Dyslipidemia (elevated LDL, decreased HDL)
 - Tobacco smoking
 -
Dyslipidemia (elevated LDL ... , decreased HDL)
Luftsichel Sign in Left Upper Lobe Collapse - Chest X-Ray

An upper lobe collapse causes the collapse
Sometimes the LLL ... the collapsed LUL ... the air in the LLL ... Luftsichel #Sign #LUL ... #Collapse #clinical
Ranson's Criteria in Pancreatitis 
At Admission: 
 - Age > 55 years 
 - WBCs >
Glucose > 200 mg/dl ... - LDH > 350 ... BUN rise > 5 mg/dl ... Calcium < 8 mg/dl
ACC/AHA Statin Guidelines - 2013 vs 2017

In 2013 the ACC/AHA guidelines drastically changed the way we
the traditional LDL ... group, if the LDL ... alternatively use the LDL ... of the target LDL ... expect a >50% LDL
Fibrates - Gemfibrozil and Fenofibrate 
Mechanism: activates PPAR alpha
Lipid Effects:
 - Decrease TG by 30-50%
 -
50% - Increase HDL ... - Decrease LDL
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH ... and kidney • LDH ... the amount of LDH ... Normal range of LDH ... elevated serum LDH
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
Algorithm • 12-13 g/dL ... reticulocyte count, LFTs, LDH