22 results
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Liver Enzymes (LFTs ... more specific for hepatic ... • R value = (ALT ... #Enzymes #LFTs ... Transaminitis #diagnosis #differential
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
Hypertension - Differential ... >10 mmHg - clinically ... • Infiltrative diseases ... sarcoidosis) • Liver ... Veno-occlusive disease
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... R-value: Serum ... replaced by non-hepatic ... disease: > 2 ... chemistry #diagnosis #differential
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... or symptoms of liver ... disease 6-9 mo ... Calculate R-Value ... Idiosyncratic #differential
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Liver Disease in ... weeks • Typical clinical ... post-partum • Typical clinical ... #Disease #Pregnancy ... hepatitis #comparison #differential
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Defects, Drugs, Liver ... Disease, PNH ... Hypophostphatemia Laboratory
Echinococcal Cysts in the Liver- The physical examination revealed hepatomegaly with a palpable hepatic mass. Laboratory
with a palpable hepatic ... Laboratory tests ... blood (normal value ... Hydatid disease ... #clinical #NEJM
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
Clinical diagnosis ... >1.5, and both values ... ) or metabolic liver ... Possible drug-induced liver ... Presence of atypical laboratory
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis ... >1.5, and both values ... ) or metabolic liver ... Possible drug-induced liver ... Presence of atypical laboratory
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
/or suspicious clinical ... disease; AST, aspartate ... disease; T2DM, ... #LFTs #Abnormal ... #Enzymes #Differential