113 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Systemic Lupus Erythematosus ... Disease, PRES Pathophysiology ... Puncture, EEG Treatment ... Systemic #Lupus #Erythematosus ... CNS #neurology #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
pericarditis • Hematologic ... proteins domain: Low ... C3 or low C4, Low ... C3 and low C4 ... #diagnosis #rheumatology
Rheumatoid Arthritis - ACR 2021 Guidelines
 - Low Disease Activity
 - Moderate to High Disease Activity
Guidelines - Low ... Tapering DMARDs - Treatment ... Guidelines #management #treatment ... #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... 60-80% - Low ... life-threatening • Treatment ... lupus #Systemic #Erythematosus ... Management #Summary #rheumatology
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Systemic Lupus Erythematosus ... Hypocomplementemia #Low ... #differential #hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low ... Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... , lymphopenia, low ... #Diagnosis #Rheumatology
Thromboelastography (TEG) based therapy and Management

If r time prolonged -> FFP
If MA low -> plts/cryoprecipitate (if
-> FFP If MA low ... Management #Diagnosis #Hematology ... Thromboelastogram #Treatment
Thromboelastography (TEG) Based Management
 - If R time prolonged -> FFP 
 - If MA low
FFP - If MA low ... TEG #Management #treatment ... #diagnosis #hematology
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
prolonged if very low ... factor VIII) Treatment ... Disease #Diagnosis #Hematology
Immunosuppressive Medications in Systemic Lupus Erythematosus (SLE)
 - MTX (oral, subcutaneous)
 - AZA (oral) 
 -
Systemic Lupus Erythematosus ... Cyclophosphamide (CYC) (iv; low ... Systemic #Lupus #Erythematosus ... #treatment