11 results
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
loop or thiazide diuretics ... pressure: Active diuretic ... Bartter syndrome, Gitelman ... result of increased excretion ... urine #Algorithm #nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
distal tubule. ↑ Nacl ... delivery to distal nephron ... ↑ K+ and ↑ H+ secretion ... → Hypokalemia Metabolic ... Pathophysiology #nephrology
Acid Base Disorders - Blood Gas Interpretation

Steps for Blood Gas Interpretation: 
1. Acidemia or Alkalemia? 
2.
) = {Na - (Cl + ... metabolic acidosis ... Volume depletion (diuresis ... Diagnosis #Summary #Nephrology ... #ABG #bloodgas
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... • Inhibit Na+ Cl ... loss through the nephron ... by excretion of ... nephrology #conversion
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Non-anion Gap Metabolic ... Generalized distal nephron ... Potassium-sparing diuretics ... ketosis with ketone excretion ... diagnosis #causes #nephrology
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Regulating Renal Excretion ... resistance • Metabolic ... #Renal #Excretion ... #Diuresis #Nephrology ... #Pharmacology #
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
• ↓ Renal K+ Excretion ... (Assess GFR), ±VBG ... suggests ↓ renal excretion ... Ca-gluconate or 1g CaCl ... Treatment #potassium #nephrology
Gitelman Syndrome - Diagnosis and Workup
Blood Work:
 - Hypokalemia
 - Hypomagnesemia
 - Metabolic Alkalosis
 - Elevated
Gitelman Syndrome ... Hypomagnesemia - Metabolic ... - Fractional excretion ... Normotensive - No diuretic ... Diagnosis #Workup #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
• K sparing diuretics ... infusions) - Metabolic ... acidosis - Hyperkalemia ... Impaired Renal Excretion ... potassium #high #nephrology
Effects of Prostaglandins and NSAIDs on the Kidney
Effects of Prostaglandins on the Kidney:
 • The vasodilatory
hormones that act ... conditions requiring excretion ... perfusion of remaining nephrons ... Kidney #renal #nephrology ... #pharmacology