68 results
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... Anti-cardiolipin (aCl ... Vasculitis: P-ANCA ... perinuclear), C-ANCA ... Autoantibodies #Rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
scleroderma) - Anti-Scl ... 80-90%) > MPO - ANCA ... MPO: 75-80% - ANCA ... disease - MPO>PR3 - ANCA ... antibodies #diagnosis #rheumatology
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... Presentation (Pulmonary ... Diagnosis for Pulmonary ... testing: anti-ANCA ... biopsy By Tess Litchman
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
With associated pulmonary ... (C-ANCA): GPA > ... > eGPA • MPO-ANCA ... (P-ANCA): eGPA, ... diagnosis #algorithm #rheumatology
Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA) - ANCA Vasculitis Management Algorithm - ACR/VF 2021
Polyangiitis (MPA) - ANCA ... Management Algorithm - ACR ... Polyangiitis #MPA #ANCA ... Vasculitis #Management #Treatment ... Guidelines #algorithm #rheumatology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Disease Associations ANA ... syndrome Anti-Scl ... Graves' disease c-ANCA ... granulomatosis p-ANCA ... diagnosis #table #rheumatology
Eosinophilic Granulomatosis with Polyangiitis (EGPA) - ANCA Vasculitis Management Algorithm - ACR/VF 2021 Guidelines
 • Active
Polyangiitis (EGPA) - ANCA ... Management Algorithm - ACR ... #Polyangiitis #ANCA ... Vasculitis #Management #Treatment ... Guidelines #algorithm #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
progressing GN • New pulmonary ... Associated - ANCA ... glomerulonephritis and/or pulmonary ... arthritis, obstructive pulmonary ... differential #diagnosis #rheumatology
Rheumatoid Arthritis - ACR 2021 Guidelines
 - Low Disease Activity
 - Moderate to High Disease Activity
Rheumatoid Arthritis - ACR ... Tapering DMARDs - Treatment ... Guidelines #management #treatment ... #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Epidemiology: -10% of all ... thiazidic, PPI, ACE ... constitutional symptoms • Treatment ... life-threatening • Treatment ... comparison #table #rheumatology