14 results
Gamma hydroxybutyrate (GHB) - Toxicology

Clinical presentation
 - Symptoms of GHB toxicity include: short term anterograde amnesia,
hydroxybutyrate (GHB) - Toxicology ... of GHB toxicity ... Hydroxybutyrate #GHB #Toxicology ... #Toxicity #Diagnosis ... #Management #Pharmacology
Carbon Monoxide Poisoning

Symptoms are non-specific:
 - Headache 90%
 - Nausea/vomiting 50%
 - Vertigo 50%
 - Altered
Monoxide Poisoning Symptoms ... affected (inc pets ... Outdoors improves symptoms ... Treatment: 100% ... Monoxide #Poisoning #Toxicology
 Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
 -
described phases of toxicity ... caustic mucosal injury ... post-ingestion) - Symptom ... caustic bowel injury ... #Toxicology #Diagnosis
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... - Diagnosis and ... ingestion/exposure Symptoms ... #Toxicology #diagnosis ... #management #Treatment
Vancomycin Associated Acute Kidney Injury

 • Drug induced acute kidney injury is generally defined as a
Associated Acute Kidney Injury ... induced acute kidney injury ... • Treatment includes ... Vancomycin #AKI #pharmacology ... #toxicology #diagnosis
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
anaerobic metabolism Diagnosis ... and acute kidney injury ... also includes symptoms ... LacticAcidosis #Toxicity ... #Toxicology #Diagnosis
Reported Mechanisms and Toxicity of Investigational Treatments for SARS-COV-2
Chloroquine and Hydroxychloroquine
 • Mechanisms: Interference with ligand
Mechanisms and Toxicity ... Investigational Treatments ... hearing loss, GI symptoms ... acidosis, renal injury ... #Toxicology #Medications
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
Induced Muscle Toxicity ... Direct muscle injury ... Risk of muscle injury ... Atorvastatin Diagnosis ... #myopathy #diagnosis
Clozapine Toxicology
Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
Clozapine Toxicology ... patients who have treatment-resistant ... effect on negative symptoms ... #Toxicity #Diagnosis ... #Pharmacology
Amiodarone Induced Lung Toxicity Summary

Who?
• 5% of patients
• Dose ≥ 400 mg per day

How?  Possible
cytotoxic lung injury ... starting amiodarone treatment ... gradually with symptoms ... Improvement in symptoms ... #management #Toxicology