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diagnosis hematology differential aflp management obstetrics pregnancy abnormal aptt bleeding bruising cascade cirrhosis comparison hellp medications obgyn prolonged pt syndrome
Coagulation Cascade and Anticoagulant Sites of Action - Amy Chung, MD, MSc https://twitter.com/AmyChung #AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
Coagulation Cascade ... #Medications #Pharmacology ... #Pathophysiology ... Mechanisms #DOAC #Hematology
Drugs and Classes Associated with DILI and Type of Liver Injury #Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Drugs and Classes ... DILI and Type of Liver ... #LiverInjury #Hepatology ... #Pharmacology # ... Causes #DILI
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 Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... • Vasculitis Coagulation ... Iatrogenic) • Liver ... Diagnosis #Algorithm #Causes ... #Hematology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
and Acute Fatty Liver ... presents with coagulation ... child * Severe cases ... pregnancy * Severe coagulation ... AFLP #obstetrics #hematology
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
presents with coagulation ... child * Severe cases ... pregnancy * Severe coagulation ... defects and liver ... Obstetrics #OBGyn #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... DIC • Severe Liver ... Treat primary cause ... #diagnosis #causes ... treatment #management #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... #differential #hematology ... #coagulation
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
vascular disorders, coagulation ... Platelet defects • Coagulation ... Kasabach-Merritt syndrome Coagulation ... deficiency • Liver ... Differential #Diagnosis #hematology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... Pregnancy (AFLP) Pathophysiology ... = nonspecific (nausea ... #Pregnancy #hepatology ... diagnosis #management #pathophysiology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Causes include : ... Pre-analytical cause ... • Reduced liver ... #differential #hematology ... #coagulation
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