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diagnosis management causes dermatology erythematosus sle joint signs symptoms systemic algorithm classification disease hemolytic myopathy myositis oncology syndrome vasculitis activation
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Rash • Human ... Malar rash ... lesions • Discoid lupus ... #rashes #differential ... #diagnosis #rheumatology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... deficiency • Fanconi’s anemia ... Diseases: • Systemic lupus ... deficiency Infections ... #Diagnosis #Hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
69% - Malar rash ... - Hemolytic anemia ... (aPL) 30-45% Differential ... Other auto-immune, Infectious ... #rheumatology
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions - Inflammatory
Vesiculobullous Skin Rash ... foliaceus - Infectious ... Bullous systemic lupus ... Vesiculobullous #SkinRash ... #dermatology #Differential
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
Inflammatory joint pain ... and fingers, or pain ... the face (many differential ... Unexplained fever, when infection ... erythematosus #rheumatology
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
Dyspnea - Differential ... Transverse myelitis • Hematology ... : - Anemia • ... Deconditioning - Pain ... #dyspnea #sob #differential
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... Photosensitivity, Butterfly rash ... lesions Abdominal pain ... ) Blood (75%): Anemia ... symptoms #diagnosis #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... usually IgG) (e.g. lupus ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Myositis and Myopathies Polymyositis • Progressive, symmetric muscle weakness • Elevated CK, +Anti-Jo, +Anti-Mi2 Dermatomyositis
muscle weakness, rash ... Rheumatica • Pain ... Diffuse muscle pain ... Myopathies #myopathy #differential ... diagnosis #comparison #rheumatology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
- Differential ... - Trauma - Infection ... lesions • Severe pain ... Autoimmune Vasculitis (lupus ... #Differential #
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