23 results
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
• Peripheral blood ... for secondary causes ... allergy, drug reaction ... glucocorticoid treatment ... Differential #diagnosis #hematology
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
the total white blood ... similarly to mast cells ... during an allergic reaction ... Or Inflammatory Reactions ... #hematology #basophils
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
- Transfusion Reactions ... of high parity blood ... without other cause ... , and CXR with pulmonary ... #hematology #diagnosis
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... TRALI): Leading cause ... potassium from lysed cells ... more likely to cause ... diagnosis #management #hematology
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Causes purpura & ... TRALI): Leading cause ... potassium from lysed cells ... more likely to cause ... diagnosis #management #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Out Secondary Causes ... factor (GCSF) treatments ... marrow studies Treatment ... Immunosuppressive treatment ... Syndromes #diagnosis #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Phagocytosis of blood ... Drugs, Unknown cause ... Treatment: • ... diagnosis #management #treatment ... #summary #rheumatology
Causes of Neutropenia - Differential Diagnosis
Neonate:
 - Infection - by far the most common cause
 -
hypertension and/or drug treatment ... Idiosyncratic drug reactions ... Idiosyncratic drug reactions-most ... including white blood ... #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
ABO incompatible blood ... + Bleeding Treatment ... Treat primary cause ... #treatment #management ... #hematology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
of about three cases ... Workup: • Full Blood ... marrow biopsy - if blood ... Hodgkin Lymphoma Treatment ... classification #hematology