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oncology rheumatology differential causes erythematosus mds myelodysplastic sle systemic thrombocytopenia activation agglutinin aplastic bleeding classification cold disease hemeonc hemolytic hemophagocytic
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Butterfly rash, Vasculitis ... Demyelinating syndromes ... ) Blood (75%): Anemia ... signs #symptoms #diagnosis ... #rheumatology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... cytopenias (usually anemia ... Myelodysplastic #Syndrome ... #hematology #oncology
Etiologies of Peripheral Neuropathy • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism • Medication-induced: ART, Antibiotics,
Guillain-Barre, Vasculitis ... , Sjogren's, Lupus ... Paraprotein-associated (POEMS syndrome ... Leah Willis via ... #differential #diagnosis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
manifestations: from easy bruising ... SJIA], systemic lupus ... with leukopenia, anemia ... #Diagnosis #Management ... #Hematology #Rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... #oncology #hematology ... #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... ANCA-associated vasculitis ... Malignancy (e.g. hematologic ... lymphopenia, low PLT • Anemia ... Erythematosus #Diagnosis
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Purpura or Easy Bruising ... SLE (systemic lupus ... infections - Vasculitis ... Scurvy #Purpura #Bruising ... peds #pediatrics #diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
blood cell count (anemia ... Easy or unusual bruising ... • Aplastic Anemia ... Megaloblastic Anemia ... #diagnosis #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Autoimmunity: • -MM/WM: Vasculitis ... (-) hemolytic anemia ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Bleeding and Bruising ... - Differential Diagnosis ... von Willebrand syndrome ... integrity == • Vasculitis ... #Hematology
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