34 results
diagnosis differential erythematosus sle systemic treatment causes leukemia monoclonal algorithm chronic cll disease hemeonc hemolytic lymphocytic mds mgus myelodysplastic workup
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... cytopenias (usually anemia ... #treatment #hematology ... #oncology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Myelodysplastic syndrome ... • Sickle cells ... alcoholism • Burr cells ... Hemolytic uremic syndrome ... #differential #hematology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Diseases: • Systemic lupus ... Differential #Diagnosis #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... #oncology #hematology ... #diagnosis #management
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
vasculitis • Hematologic ... Abnormalities: macrocytic anemia ... criteria for 1) hematologic ... blood myeloid cells ... Autoinflammatory #Somatic #rheumatology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
• Systemic Lupus ... Reed-Sternberg Cells ... Algorithm #Causes #Hematology ... #Oncology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Systemic lupus ... SJIA], systemic lupus ... with leukopenia, anemia ... #Diagnosis #Management ... #Hematology #Rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... Demyelinating syndromes ... ) Blood (75%): Anemia ... Thrombocytopenia #Lupus ... symptoms #diagnosis #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... Hemolytic uremic syndrome ... usually IgG) (e.g. lupus ... differential #diagnosis #hematology ... #anemia
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... block • Sjogren syndrome ... #Systemic #Lupus ... Summary #diagnosis #rheumatology ... #management
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