113 results
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
Blood Disorders ... - Markers and Differential ... Pelger-Huet, Macrocytic anemia ... or λ), Smudge Cells ... @AmyChung #Blood
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Peripheral Blood ... Sickled red cells ... disease Bite cells ... #Peripheral #Blood ... Analysis #hematology #microscopy
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
- Differential ... • Peripheral blood ... History • Bite cells ... Fevers, DAT (-) → Infection ... #Differential #
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Thrombocytosis - Differential ... Reactive: • Anemia ... /blood loss (Fe ... deficiency) • Infection ... Sepsis • Non-infectious
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... petechiae) • Frequent infections ... Neutropenia • Platelet Disorders ... • Parvovirus infection ... count with differential
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
, autoimmune disorder ... Immunoglobulin M (IgM) • Blood ... younger pts) Differential ... sensitize red blood ... cells (RBCs) at
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... disease, McLeod blood ... Unstable hemoglobin disorders ... RBC #Morphology #differential ... diagnosis #hematology #microscopy
Diagnostic Criteria for Scleroderma Renal Crisis 

1. New onset blood pressure >150/85 mm Hg OR increase
New onset blood ... Microangiopathic hemolytic anemia ... examination - Microscopic ... cells on urine ... microscopy -
Red cell autoagglutination is the process whereby red cells clump together forming aggregates. This is seen
agglutinin disease and Infection ... Mycoplasma Pneumonia or Infectious ... individual’s red blood ... Clinical #Path #Blood ... #Smear #Microscopy
Red cell autoagglutination is the process whereby red cells clump together forming aggregates. This is seen
agglutinin disease and Infection ... Mycoplasma Pneumonia or Infectious ... individual’s red blood ... Clinical #Path #Blood ... #Smear #Microscopy