21 results
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Peripheral Blood ... Smear Analysis ... Microangiopathic hemolytic ... #Smear #Analysis ... #hematology #microscopy
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Autoimmune: Warm AIHA, Cold ... - Peripheral Blood ... Smear ↑ abnormal ... Diagnosis #hematology
Red cell autoagglutination is the process whereby red cells clump together forming aggregates. This is seen
macroglobulinemia, cold ... individual’s red blood ... cells (RBCs or ... Clinical #Path #Blood ... #Smear #Microscopy
Red cell autoagglutination is the process whereby red cells clump together forming aggregates. This is seen
macroglobulinemia, cold ... individual’s red blood ... cells (RBCs or ... Clinical #Path #Blood ... #Smear #Microscopy
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Antibody Autoimmune Hemolytic ... ↑ LDH • Anti-RBC ... type ± C3d • Blood ... smear: Differential ... management #treatment #rheumatology
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
- Differential ... • Peripheral blood ... smear + DAT + further ... Hypochromic & microcytic RBCs ... #Anemia #Differential
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... disease, McLeod blood ... #Morphology #differential ... #diagnosis #hematology ... #microscopy #atlas
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
smear - RBC agglutination ... younger pts) Differential ... sensitize red blood ... cells (RBCs) at ... #anemia #hematology
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
Peripheral blood ... polychromatophilic cells ... #anemia #Hematology ... #Pathology #Smear ... #Microscopy
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Algorithm • Sickle cells ... Agglutination - Cold ... #Anemia #Differential ... Algorithm #workup #hematology