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hematology oncology management syndrome differential mds myelodysplastic algorithm aplastic canimorsus capnocytophaga chronic clinical cll coagulation damage dic disseminated exposure gap
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
= funny-shaped cells ... old, ~10,000 new cases ... cytopenias (usually anemia ... transformation to acute ... leukemia Management
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Chronic Myelogenous Leukemia ... Infectious: • Acute ... effect following treatment ... Iron deficiency anemia ... #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... - infiltrates (anemia ... CLL -> Invade Skin ... #Hematology #Oncology ... #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... • Neutropenia, anemia ... microglobulin Treatment ... ’s lymphoma or acute ... #diagnosis #workup
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... and petechiae Causes ... virus (EBV) • Leukemia ... Treatment: ... #diagnosis #management
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... malignancy (Especially acute ... promyelocytic leukemia ... #Coagulation #diagnosis ... #causes #treatment
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Sweet Syndrome Acute ... Causes: - Idiopathic ... cutis Diagnosis ... Treatment: - Systemic ... #dermatology #oncology
Capnocytophaga Canimorsus Skin Rash 40 M presents w/ N, V, severe epigastric pain. SHx: smoker, drinks 18
Bandemia, AKI. ... selsis after a ... the key to the diagnosis ... #Rash #dermatology ... #clinical #photo
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
sweats (28%) • Skin ... decrease (<200 cells ... enzymes ↑ • Mild anemia ... antibody test) Treatment ... Syndrome #HIV #diagnosis
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