20 results
Multiple Myeloma Diagnosis and Management Summary
Clinical Signs:
 • hyperCalcemia 28% (bone demineralization)
 • Renal disease 48%
Multiple Myeloma ... Diagnosis and Management ... osteolytic lesions and pathologic ... marrow plasma cells ... #Multiple #Myeloma
Back Pain - Differential Diagnosis
Primary Back Pathology:
 • Musculoligamentous injury (a.k.a. lumbosacral strain)
 • Spondylosis (i.e.
Back Pain - Differential ... Diagnosis Primary ... Back Pathology: ... , thyroid, and myeloma ... #Diagnosis #causes
Non-cirrhotic Hyperammonemia - Differential Diagnosis Framework

Hematologic & Vascular:
 • Multiple myeloma & Acute leukemia (plasma cells
Hyperammonemia - Differential ... Diagnosis Framework ... : • Multiple myeloma ... leukemia (plasma cells ... #Diagnosis #Pathophysiology
Etiologies of Peripheral Neuropathy
 • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism
 • Medication-induced: ART, Antibiotics,
POEMS syndrome, myeloma ... Leah Willis via ... Peripheral #Neuropathy #differential ... #diagnosis #causes
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Willebrand Syndrome - Diagnosis ... lymphoma, multiple myeloma ... adsorption onto cancer cells ... vonWillebrand #Syndrome #Diagnosis ... treatment #hematology #differential
Pathologic / Fragility Fractures - Differential Diagnosis Algorithm 
Tumours
 - See Bone Lesions Scheme
Paget's Disease
 -
Pathologic / Fragility ... Fractures - Differential ... Diagnosis Algorithm ... - Skull/spine/Pelvis ... #MSK #Differential
IgG4-associated conditions

Diagnosis of IgG4 disease is depending on BIOPSY. While IgG4 levels can be informative (and
conditions Diagnosis ... positive plasma cells ... Even the pathology ... conditions #diseases #differential ... #diagnosis
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
Basophilia - Differential ... Diagnosis Framework ... similarly to mast cells ... Disorders: • Chronic myeloid ... #Diagnosis #causes
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Volume (MCV) - Differential ... Diagnosis Algorithm ... Formation • Multiple Myeloma ... Macrocytosis, Target Cells ... #Diagnosis #Algorithm
Castleman's Disease and Associated Syndromes
HYALINE VASCULAR VARIANT
 • unicentric, HHV8-ve, children and young.
 • Hyalinized vessels
Diffuse plasma cells ... cell disorders (myeloma ... Disease #Variants #Diagnosis ... #Pathology