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clinical leukemia management multiple oncology adult atll cell conditions differential disease diseases hematology igg4 indolent itlbp largegranular lymphocytic lymphoma plasmacytoma
Castleman's Disease and Associated Syndromes HYALINE VASCULAR VARIANT • unicentric, HHV8-ve, children and young. • Hyalinized vessels
Castleman's Disease ... Diffuse plasma cells ... cell disorders (myeloma ... Disease #Variants #Diagnosis ... #Pathology
IgG4-associated conditions Diagnosis of IgG4 disease is depending on BIOPSY. While IgG4 levels can be informative (and
conditions Diagnosis ... really need to see pathology ... positive plasma cells ... Even the pathology ... polyangiitis, and Castleman
Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
Multiple Myeloma ... Diagnosis and Management ... osteolytic lesions and pathologic ... marrow plasma cells ... #Multiple #Myeloma
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia Clinical - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
required for dx - T-cells ... chronic LPD of NK cells ... are NK cells (sCD3 ... Lymphocytic #Leukemia #hemepath ... #pathology #diagnosis
Indolent T-Lymphoblastic Proliferation (iT-LBP) Features of iT-LBP: - May be seen in association with other malignancies (e.g.
Groups of TdT+ T-cells ... Proliferation #Hemepath ... #pathology #Clinical ... #diagnosis
Adult T-cell Leukemia / Lymphoma (ATLL) - Mimicking Angioimmunoblastic T-cell lymphoma with Hodgkin like cells Features ATLL:
with Hodgkin like cells ... Leukemia #Lymphoma #Hemepath ... #pathology #Clinical ... #diagnosis
Raindrop Skull- ...A skeletal survey showed diffuse osteopenia, a pubic bone fracture, and numerous radiolucent lesions
characteristic of multiple myeloma ... The diagnosis was ... clonal plasma cells ... #NEJM #clinical ... raindrop #multiple #myeloma
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Diagnosis? ... patients with EMD myeloma ... Diagnostic Evaluation ... IFE, FLC assay Pathology ... • Multiple myeloma
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
of multicentric Castleman ... overgrowth of cells ... including lymphoma, myeloma ... Histopathological Diagnoses ... agonists #TAFRO #diagnosis
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