7 results
Castleman's Disease and Associated Syndromes
HYALINE VASCULAR VARIANT
 • unicentric, HHV8-ve, children and young.
 • Hyalinized vessels
Castleman's Disease ... Diffuse plasma cells ... disorders (myeloma ... Disease #Variants #Diagnosis ... #Pathology
Multiple Myeloma Diagnosis and Management Summary
Clinical Signs:
 • hyperCalcemia 28% (bone demineralization)
 • Renal disease 48%
Multiple Myeloma ... Summary Clinical ... osteolytic lesions and pathologic ... marrow plasma cells ... plasma clonal cell
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia
Clinical
 - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
required for dx - T-cells ... chronic LPD of NK cells ... disease but cells ... are NK cells (sCD3 ... #pathology #diagnosis
Adult T-cell Leukemia / Lymphoma (ATLL) - Mimicking Angioimmunoblastic T-cell lymphoma with Hodgkin like cells

Features ATLL:
Adult T-cell Leukemia ... with Hodgkin like cells ... Leukemia #Lymphoma #Hemepath ... #pathology #Clinical ... #diagnosis
Indolent T-Lymphoblastic Proliferation (iT-LBP)
Features of iT-LBP:
 - May be seen in association with other malignancies (e.g.
follicular dendritic cell ... Groups of TdT+ T-cells ... Proliferation #Hemepath ... #pathology #Clinical ... #diagnosis
Raindrop Skull- ...A skeletal survey showed diffuse osteopenia, a pubic bone fracture, and numerous radiolucent lesions
characteristic of multiple myeloma ... The diagnosis was ... clonal plasma cells ... #NEJM #clinical ... raindrop #multiple #myeloma
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
arises from plasma cells ... from the plasma cells ... plasmacytoma) Clinical ... monoclonal plasma cells ... clonal plasma cells