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clinical hematology leukemia lymphoma multiple oncology adult alkpos anaplastic atll castlemans cell differential disease gitract itlbp largecell largegranular lymphocytic lymphoid
A summary of GI Lymphomas - Primary Lymphoid Neoplasms of the GI Tract T-Cell - EATL -
- MEITL - Indolent ... GITract #hematology #hemepath ... #pathology #differential ... #diagnosis
Indolent T-Lymphoblastic Proliferation (iT-LBP) Features of iT-LBP: - May be seen in association with other malignancies (e.g.
Indolent T-Lymphoblastic ... Groups of TdT+ T-cells ... Proliferation #Hemepath ... #pathology #Clinical ... #diagnosis
Anaplastic large cell lymphoma, ALK+ Clinical • First 3 decades of life, M>F • Often nodal +
skin - may be indolent ... hof (Hallmark cells ... ) • Donut cells ... lymphoma #ALKPos #hemepath ... #pathology
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia Clinical - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
required for dx - T-cells ... are NK cells (sCD3 ... similar, both are indolent ... Lymphocytic #Leukemia #hemepath ... #pathology #diagnosis
Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
Multiple Myeloma ... Diagnosis and Management ... osteolytic lesions and pathologic ... marrow plasma cells ... #Multiple #Myeloma
Castleman's Disease and Associated Syndromes HYALINE VASCULAR VARIANT • unicentric, HHV8-ve, children and young. • Hyalinized vessels
Diffuse plasma cells ... cell disorders (myeloma ... Disease #Variants #Diagnosis ... #Pathology
Adult T-cell Leukemia / Lymphoma (ATLL) - Mimicking Angioimmunoblastic T-cell lymphoma with Hodgkin like cells Features ATLL:
with Hodgkin like cells ... Leukemia #Lymphoma #Hemepath ... #pathology #Clinical ... #diagnosis
Raindrop Skull- ...A skeletal survey showed diffuse osteopenia, a pubic bone fracture, and numerous radiolucent lesions
characteristic of multiple myeloma ... The diagnosis was ... clonal plasma cells ... #NEJM #clinical ... raindrop #multiple #myeloma
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Diagnosis? ... patients with EMD myeloma ... Diagnostic Evaluation ... IFE, FLC assay Pathology ... • Multiple myeloma
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