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clinical leukemia oncology differential hematology multiple adult atll brittle castlemans cell comparison conditions cryptococcus derm dermatology disease diseases gram hair
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Leukemia): • Lymphocytes ... CML (Chronic Myeloid ... • Neutrophils (myeloid ... AML (Acute Myeloid ... Hematology #Oncology #Diagnosis
T-LGL leukemia - T-CeIl Large Granular Lymphocytic Leukemia Clinical - Persistent (>6mo) lymphocytosis (2-20k) with proven clonality
Large Granular Lymphocytic ... are NK cells (sCD3 ... LargeGranular #Lymphocytic ... #Leukemia #hemepath ... #pathology #diagnosis
Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
Multiple Myeloma ... Diagnosis and Management ... osteolytic lesions and pathologic ... marrow plasma cells ... #Multiple #Myeloma
IgG4-associated conditions Diagnosis of IgG4 disease is depending on BIOPSY. While IgG4 levels can be informative (and
conditions Diagnosis ... really need to see pathology ... positive plasma cells ... and lymphocytes ... Even the pathology
Cryptococcus neoformans Meningoencephalitis- The opening pressure on lumbar puncture was 29 cm of water (reference range,
count was 340 cells ... 90% mononuclear cells ... predominantly lymphocytes ... #clinical #NEJM ... stain #indiaInk #pathology
Castleman's Disease and Associated Syndromes HYALINE VASCULAR VARIANT • unicentric, HHV8-ve, children and young. • Hyalinized vessels
Diffuse plasma cells ... cell disorders (myeloma ... Disease #Variants #Diagnosis ... #Pathology
Scleroderma Like Conditions - Differential Diagnosis Eosinophilic Fasciitis: - Orange peel induration (peau d'orange) of proximal extremities
- Differential Diagnosis ... biopsy demonstrates lymphocytes ... , plasma cells, ... setting of multiple myeloma ... #Differential #Diagnosis
Indolent T-Lymphoblastic Proliferation (iT-LBP) Features of iT-LBP: - May be seen in association with other malignancies (e.g.
Groups of TdT+ T-cells ... Proliferation #Hemepath ... #pathology #Clinical ... #diagnosis
Adult T-cell Leukemia / Lymphoma (ATLL) - Mimicking Angioimmunoblastic T-cell lymphoma with Hodgkin like cells Features ATLL:
with Hodgkin like cells ... Leukemia #Lymphoma #Hemepath ... #pathology #Clinical ... #diagnosis
Raindrop Skull- ...A skeletal survey showed diffuse osteopenia, a pubic bone fracture, and numerous radiolucent lesions
characteristic of multiple myeloma ... The diagnosis was ... clonal plasma cells ... #NEJM #clinical ... raindrop #multiple #myeloma
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