15 results
Multiple Myeloma Diagnosis and Management Summary
Clinical Signs:
 • hyperCalcemia 28% (bone demineralization)
 • Renal disease 48%
Multiple Myeloma ... osteolytic lesions and pathologic ... marrow plasma cells ... #Multiple #Myeloma ... #oncology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
to IgM multiple myeloma ... marrow plasma cells ... to light-chain myeloma ... Significance #hematology #diagnosis ... #oncology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Multiple Myeloma ... and Monoclonal ... if this is is monoclonal ... Gammopathies #MGUS #diagnosis ... #hematology #oncology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
- Differential Diagnosis ... Lymphocytes) - Monoclonal ... Reed-Sternberg Cells ... #Differential #Diagnosis ... Causes #Hematology #Oncology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Can Feature A Monoclonal ... POEMS (Sclerotic myeloma ... POEMS (Sclerotic myeloma ... #Differential #Diagnosis ... #Oncology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
- Idiopathic monoclonal ... Diagnosis: • hemolytic ... Monoclonal IgM ... significance (MGUS), CLL, Myeloma ... sensitize red blood cells
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Syndrome (MD) - Diagnosis ... Management Summary myelo ... = funny-shaped cells ... 10,000 new cases diagnosed ... treatment #hematology #oncology
Macroglossia in Light-Chain Amyloidosis- Physical examination revealed macroglossia, with indentations from the teeth (Panel A)...A biopsy
findings confirmed a diagnosis ... , amyloidosis, monoclonal ... Early diagnosis ... amyloidosis #clinical #photo ... AL #lightchain #NEJM
Raindrop Skull- ...A skeletal survey showed diffuse osteopenia, a pubic bone fracture, and numerous radiolucent lesions
The diagnosis was ... clonal plasma cells ... electrophoresis revealed a monoclonal ... #NEJM #clinical ... raindrop #multiple #myeloma
Castleman's Disease and Associated Syndromes
HYALINE VASCULAR VARIANT
 • unicentric, HHV8-ve, children and young.
 • Hyalinized vessels
Diffuse plasma cells ... cell disorders (myeloma ... Disease #Variants #Diagnosis ... #Pathology