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hematology management syndrome anemia clinical differential mds multiple algorithm aplastic autoinflammatory castlemans causes cell cutaneous dermatology disease e1 elevatedmcv gammopathy
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
, myelodysplastic ... conditions - multiple myeloma ... or myelodysplastic ... peripheral blood myeloid ... cells NEJM Review
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic ... Management Summary myelo ... = funny-shaped cells ... BrighamChiefs #Myelodysplastic ... treatment #hematology #oncology
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
associated with myelodysplastic ... syndrome • Myeloid ... manifestations #myelodysplastic ... #differential #diagnosis ... #dermatology #oncology
Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
Multiple Myeloma ... osteolytic lesions and pathologic ... marrow plasma cells ... #Multiple #Myeloma ... #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic ... Myelodysplastic ... , or all three myeloid ... #Syndromes #diagnosis ... #hematology #oncology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
- Differential Diagnosis ... Formation • Multiple Myeloma ... Dysplastic • Myelodysplastic ... Macrocytosis, Target Cells ... #Differential #Diagnosis
Castleman's Disease and Associated Syndromes HYALINE VASCULAR VARIANT • unicentric, HHV8-ve, children and young. • Hyalinized vessels
Diffuse plasma cells ... cell disorders (myeloma ... Disease #Variants #Diagnosis ... #Pathology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
• Hypocellular myelodysplastic ... number of CD34+ cells ... number of CD34+ cells ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
to IgM multiple myeloma ... marrow plasma cells ... to light-chain myeloma ... Significance #hematology #diagnosis ... #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
CML (Chronic Myeloid ... • Neutrophils (myeloid ... AML (Acute Myeloid ... Leukemia #Hematology #Oncology ... #Diagnosis
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