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hematology oncology clinical management rheumatology smear differential mds myelodysplastic amyloid anemia asplenia autoinflammatory babesia babesiosis bloodsmear chronic comparison conditions derm
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blasts in the peripheral ... blood smear or ... develop leukostasis syndrome ... • Tumor lysis syndrome ... Hematology #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... cytometry • Peripheral ... Lymphocytosis: Absolute blood ... aplasia • ITP ... #diagnosis #workup
Plasmacytomas and Plasma-Cell Leukemia - Physical examination revealed multiple exophytic subcutaneous lesions involving the arms and
Plasmacytomas and Plasma-Cell ... Leukemia - Physical ... A peripheral-blood ... revealed 25% plasma cells ... #Smear #NEJM
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
) Peripheral ... Causes • Anemia • Aplastic ... Chronic Myelogenous Leukemia ... Cell Leukemia ... #diagnosis #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... virus (EBV) • Leukemia ... anemia) Labs: • Peripheral ... result from low blood ... oncology #hematology #diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... dys- (abnormal) -plastic ... = funny-shaped cells ... transformation to acute leukemia ... Allogeneic stem cell
Amyloidosis - Summary Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
: • Nephrotic syndrome ... Carpal tunnel syndrome ... Increased plasma cells ... and stocking" peripheral ... Blood Tests:
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
neuritis - Giant cell ... Lyme disease • Peripheral ... arteritis • Bloody ... • Diminished peripheral ... #differential #diagnosis
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
(12%) • giant cell ... hematopoietic stem cells ... including peripheral ... blood myeloid cells ... NEJM Review: https
Howell-Jolly Body - On these Wright-stained peripheral blood smears the small dark spheres within red cells
Wright-stained peripheral ... blood smears the ... in the right photo ... thalassemia, and leukemia ... Path #BloodSmear #Blood
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