12 results
Erythroderma - Diagnostic Algorithm. Pathophysiology: 1) Extensive cutaneous capillary dilation, results in widespread exfoliation of the
Erythroderma - Diagnostic Algorithm ... Pathophysiology: ... Skin-homing T-cells ... Erythroderma #Nikolsky #Algorithm ... #Differential #Ddxof
Acute Otitis Media: Complications
Infection and inflammation of the middle ear
 - Prolonged obstruction of e. tube
to mastoid air cells ... severe Signs/Symptoms ... /Complications ... #pathophysiology ... #symptoms #signs
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
B and CD-4+ T cells ... RheumaticFever #pathophysiology ... diagnosis #signs #symptoms ... #complications
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
mutated in all cells ... Retinoblastoma Signs / Symptoms ... / Complications ... Retinoblastoma #pathophysiology ... diagnosis #signs #symptoms
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
lymphocytes, smudge cells ... Splenomegaly 5) Symptoms ... thrombocytopenia Complications ... Constitutional symptoms ... Lymphocytic #Leukemia #oncology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... (LP) tumour B cells ... pattern of spread, B symptoms ... Classification #pathophysiology ... #differential #algorithm
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
with no early symptoms ... or basket cells ... kinase (BTK) Complications ... leukemia • GI complications ... diagnosis #workup #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... chronic onset of symptoms ... B-cell lineage ALL Symptoms ... Transformation: • Complication ... Leukemia #Hematology #Oncology
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
• Langerhan cells ... removal of these cells ... Manifestations #pathophysiology ... diagnosis #signs #symptoms ... #complications
Mastoiditis: Pathogenesis and clinical findings

Acute or Chronic Otitis Media -> 
Stage 1: Hyperemeia of the mastoid
the mastoid air cells ... and mastoid air cells ... #Mastoiditis #pathophysiology ... #signs #symptoms ... #diagnosis #otology