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diagnosis differential management algorithm signs symptoms syndrome rheumatology hepatology treatment chronic classification hemeonc leukemia aplastic cardiology cll crisis dermatology emergencies
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... Definition • Pathophysiology ... #Aplastic #Anemia ... #diagnosis #oncology ... #hematololgy
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... , Target Cells ... #Normocytic #Anemia ... Diagnosis #Algorithm #Causes ... #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
transfusion • Target cells ... • Sickle cells ... alcoholism • Burr cells ... PD deficiency, Pulmonary ... #differential #hematology
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
- Tamponade Pulmonary ... Vasculature: - PE - Pulmonary ... Transverse myelitis • Hematology ... : - Anemia • ... #pulmonary
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
= funny-shaped cells ... old, ~10,000 new cases ... cytopenias (usually anemia ... Management #treatment #hematology ... #oncology
Oxyhemoglobin Dissociation Curve Left Shift - decreased unloading of O2 at tissue level (i.e. increased
stored red blood cells ... • chronic anæmia ... - Sickle cell anemia ... Dissociation #Curve #Pathophysiology ... #Differential #Causes
Tachypnea - Differential Diagnosis Framework Definitions • Tachypnea: Respiratory rate > 20/min, shallow breathing in adults •
deep breathing Pulmonary ... Tachypnea: • Pulmonary ... effusion/Tamponade Hematologic ... : • Anemia ... Differential #Diagnosis #pulmonary
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... and petechiae Causes ... number of CD34+ cells ... #oncology #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... • Pernicious Anemia ... Macrocytosis, Target Cells ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Reed-Sternberg Cells ... Diagnosis #Algorithm #Causes ... #Hematology #Oncology
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