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classification cardiology diagnosis differential antiarrhythmics causes hypokalemia potassium adrenoceptor comparison digoxin disorders hematology lymphomas lymphoproliferative nonhodgkin phases receptors table vaughan
Antiarrhythmics - Vaughan Williams Classification: CLASS 1 - Sodium Channel Blockers: • MOA: Block fast Na+ channels
Action, ←→ EFR ... block alpha & beta adrenergic ... ++ influx into cells ... Vaughan #Williams #Pharmacology ... #pathophysiology
Antiarrhythmics Pharmacology Summary Cardiac Conduction Phases: Phase 0 - Ventricular Depolarization: • Na+ channels open leading to a
Antiarrhythmics Pharmacology ... Action, ←→ EFR ... block alpha & beta adrenergic ... Antiarrhythmics #Pharmacology ... #pathophysiology
Hypokalemia Differential Diagnosis Algorithm Low intake • poor oral intake Renal loss • Medication • Hypomagnesemia •
Differential Diagnosis Algorithm ... Low intake ... Nonreabsorbable anions ... Alkalemia • Adrenergic ... #Causes #Classification
Antiarrhythmics - Vaughan Williams Classification Class I (Ia, Ib, Ic) - Na+ Channel Blockade • Slows depolarization
depolarization in slow ... AP cells • Slows ... Blockade • Prolongs action ... AP cells • Slow ... #cardiology #pharmacology
Causes of Hypokalemia - Differential Diagnosis Algorithm Increased Loss - Increased GI Loss - Increased Urinary
Causes of Hypokalemia ... Differential Diagnosis Algorithm ... Differential #Diagnosis #Algorithm ... #causes #potassium ... #low #pathophysiology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... are present • Classic ... B-Cell ~90% • Low ... Classification #pathophysiology ... #differential #algorithm
Adrenoceptor Actions α1 • Vascular smooth muscle - Contraction • Genitourinary smooth muscle - Contraction • Intestinal
Adrenoceptor Actions ... #Adrenoceptor #adrenergic ... #receptors #actions ... #pharmacology # ... pathophysiology
Digoxin Pharmacology and Pathophysiology 1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... and Pathophysiology ... intracellular calcium causes ... hypokalemia (or low ... #Pathophysiology
Causes of Hypokalemia I. Decreased intake A. Starvation B. Clay ingestion II. Redistribution into
Causes of Hypokalemia ... Redistribution into cells ... Increased ß2-adrenergic ... nonreabsorbed anions ... Differential #Diagnosis #Low
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