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diagnosis oncology rheumatology hemeonc thrombocytopenia acquired algorithm anemia anticoagulant aplastic apml cardiology causes chemotherapy coagulation cyp3a4 decisionaid dic differential differentiation
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓) of cytochrome p450 CYP3A4 and P-glycoprotein. DOACs are substrates
(DOAC interactions ... ) Cancer-treatment ... Chemotherapy #Oncology #Hematology ... #Interactions #Table ... #Pharmacology
DOAC Reversal Emergency surgery or urgent procedure Stop anticoagulant treatment; volume resuscitation and transfusion as needed Antidotes: • Apixaban,
DOAC Reversal Emergency ... anticoagulant treatment ... not available #DOAC ... anticoagulant #hematology ... #management #pharmacology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... only curative treatment ... Myelodysplastic #Syndrome ... #treatment #hematology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... Diagnosis and Management ... adsorption onto cancer cells ... vonWillebrand #Syndrome ... #treatment #hematology
Managing warfarin INR Warfarin dosage must be individualized according to the patient's response to the drug, and
#management #algorithm ... #pharmacology # ... treatment #medications ... #table #pharmacotherapy ... decisionaid #cardiology #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... : • Pathophysiology ... Lysis of tumor cells ... TLS #diagnosis #management ... #hematology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
Diagnosis and Management ... ♀, ↑Age, ESRD Pathophysiology ... Management: • ... , Bivalirudin, DOAC ... #Treatment #Hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Pathophysiology ... APML #diagnosis #management ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... aplastic anemia Treatment ... Anemia #oncology #hematology ... #diagnosis #management
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
, breast bone, pelvis ... and lower jaw Treatment ... #Rheumatology # ... diagnosis #management ... #Dermatology
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