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diagnosis management differential dermatology rheumatology treatment anemia cancer classification comparison hodgkins leukemia lymphoma mds myelodysplastic nephrology sideeffects workup acute adverse
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Diagnosis Framework HEMATOLOGIC ... Hyperviscosity Syndrome ... neutrophil count < 500 cells ... New-onset back pain ... Dyspnea, chest pain
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... = funny-shaped cells ... Myelodysplastic #Syndrome ... Management #treatment #hematology ... #oncology
Diagnostic criteria for Neutropenic Enterocolitis (NEC) Major Criteria: • Neutropenia (ANC <500 x 10^9 cells/L) • Bowel
ANC <500 x 10^9 cells ... • Abdominal pain ... Diagnosis #criteria #hematology ... #oncology
Acute Kidney Injury (AKI) in Patients with Cancer Cancer Related • Hypercalcemia • Intravenous contrast •
change disease • Hematologic ... Capillary leak syndrome ... • Tumor lysis syndrome ... Methotrexate • AIN ... #AKI #Cancer #Oncology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Alcohol-induced pain ... : Pain in involved ... Lymphomas • Other hematologic ... NonHodgkins #comparison #oncology ... #differential #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
infections, bone pain ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
malaise) - Muscle pain ... Inflammation and pain ... , breast CA - Hematologic ... #diagnosis #dermatology ... #oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Release from blast cells ... effusions, weight gain ... diagnosis #management #hematology ... #oncology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓) of cytochrome p450 CYP3A4 and P-glycoprotein. DOACs are substrates
#Chemotherapy #Oncology ... #Hematology #Interactions ... #Table #Pharmacology
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