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hematology management causes differential leukemia mds myelodysplastic acidosis anemia apml bruising cell chronic classification cll dendritic differentiation elevation emergencies hemeonc
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... HIV • Immune Aplastic ... #Anemia #oncology ... #hematology #diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... dys- (abnormal) -plastic ... = funny-shaped cells ... Myelodysplastic #Syndrome ... treatment #hematology #oncology
Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) • Plasmacytoid Dendritic Cells (pDC) Neoplasms • BPDCN • BPDCN
Blastic Plasmacytoid ... Plasmacytoid Dendritic Cells ... @ZhuoerXie #Blastic ... Cell #Neoplasm #diagnosis ... #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Causes • Anemia • Aplastic ... with excess blasts ... (blasts) are found ... #diagnosis #hematology ... #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
cells - Blood & ... develop leukostasis syndrome ... • Tumor lysis syndrome ... Leukemia #Hematology #Oncology ... #Diagnosis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Cytokine Release from blast ... cells → SIRS response ... damage • Induce blast ... management #hematology #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
phenomenon CLL Diagnosis ... Pure red cell aplasia ... • Richter’s Syndrome ... leukemia • Sezary syndrome ... #workup #oncology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Haemolytic uraemic syndrome ... Kasabach—Merritt syndrome ... Acquired - Aplastic ... Bruising #Causes #peds ... #pediatrics #diagnosis
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
- Differential Diagnosis ... e.g., uptake by cells ... / hypoxemia -> focus ... laboratory or diagnostic ... - Compartment syndrome
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Summary of Oncologic ... interventional radiology ... “big & sticky” cells ... #Emergencies #Oncology ... #HemeOnc #Diagnosis
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