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diagnosis management differential cancer emergencies oncologic tumor acute aki causes classification hemeonc injury k kidney leukostasis potassium rhabdomyolysis tumorlysis uricacid
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric
Classification of Tumor Lysis ... Syndrome (TLS) ... hydroxide • Hyperkalemia ... #TumorLysis #Syndrome ... #management #oncology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
leukapheresis - TLS ... cells releasing ... hydration - Hyperkalemia ... #Syndrome #TLS ... diagnosis #management #hematology
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... malignancies Treatments ... 6L/day) • For hyperkalemia ... #Syndrome #TLS ... #oncology #management
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Diagnosis Framework HEMATOLOGIC ... neutrophil count < 500 cells ... EMERGENCIES: Tumor Lysis ... Hyperphosphatemia • Hyperkalemia ... Hypocalcemia Hypercalcemia
Acute Kidney Injury (AKI) in Patients with Cancer Cancer Related • Hypercalcemia • Intravenous contrast •
Cancer Related • Hypercalcemia ... change disease • Hematologic ... malignancies Treatment ... #AKI #Cancer #Oncology ... Classification #Nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Acidosis, Cell Lysis ... (TLS, rhabdo/crush ... acidosis), CK+LDH (lysis ... Drives K+ into cells ... #potassium #nephrology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
- Compartment syndrome ... HIV, Influenza, TSS ... or compartment syndrome ... kidney tubular cells ... #nephrology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
antibiotics TLS ... (tumor-lysis syndrome ... ): - Hematologic ... low Ca - q8 h TLS ... plasmapheresis Hypercalcemia
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