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diagnosis hematology differential management nephrology algorithm leukemia renal rheumatology anemia blood cancer casts causes chronic cll comparison gout hematuria lymphocytic
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Hyperviscosity Syndrome ... Leukostasis: • WBC ... Superior Vena Cava Syndrome ... : Tumor Lysis Syndrome ... Vomiting, decreased urine
Lower Urinary Tract Infection: Pathogenesis and Clinical Findings - Predisposing Factors: Immunocompromised state, diabetes, elderly, female
urethra), stagnant urine ... Malaise, Incr WBC ... CFU/L) Incr WBC ... (>10 WBC/gL) ... (+) Nitrites, Leukocyte
Nephritic vs Nephrotic Syndrome Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes. Step
Nephritic vs Nephrotic Syndrome ... nephrotic/nephritic syndromes ... glomerular hematuria (RBC ... dysmorphic RBCs in urine ... Nephritic #Nephrotic #Syndrome
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Proteinuria (Negative urine ... • Fanconi's syndrome ... Proteinuria (Positive urine ... sediment - WBC/ ... RBC casts
Urinalysis & Urine Sodium Theophilus Protospatharius, a seventh-century physician who wrote the first manuscript focused exclusively
Urinalysis & Urine ... exclusively on urine ... • Ketones • Leukocyte ... Red blood cells (RBC ... dipstick #nitrite #leucocyte-esterase
Glomerular Diseases - Nephritic and Nephrotic Syndromes Nephritic syndrome—due to GBM disruption. Hypertension. t BUN and creatinine.
and Nephrotic Syndromes ... Nephritic syndrome—due ... RBC casts in urine ... Nephrotic yndrome—podocyte ... Nephritic #Nephrotic #Syndromes
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
• Blasts > 10% leukocytes ... develop leukostasis syndrome ... AML Dx: • ↑ Leukocyte ... • Tumor lysis syndrome ... Leukemia #Hematology #Oncology
Urine Microscopy - Casts Acellular Casts • Hyaline Casts - Consists of only precipitated Tamm-Horsfell protein without
Urine Microscopy ... suggestive of nephrotic sydnrome ... Cellular Casts: • RBC ... glomerulonephritis • WBC ... EricsMedicalLectures/ #Casts #Urine
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
disease - Alport syndrome ... pain hematuria syndrome ... hematuria: - RBC ... - Dysmorphic RBC ... • Nutcracker syndrome
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... if high risk if WBC ... QD until normal WBC ... Differentiation #Syndrome ... management #hematology #oncology
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