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diagnosis management hematology symptoms causes erythematosus lupus systemic arthritis classification disease hemophagocytic infections infectiousdiseases joint lymphohistiocytosis pain algorithm cns disorders
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Periodic fever ... multiorgan failure • Fever ... - Nonremitting fever ... erythematosus [SLE ... ALT ↑ bilirubin level
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... signs and symptoms ... following: • Fever ... • Bicytopenia Treatment ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... : fever +++, hepatosplenomegaly ... , ↓ Fibrinogen level ... Autoimmune diseases: SLE ... #summary #rheumatology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Hyperthyroidism Fever ... • Rheumatic fever ... Neurologic system ... , Rheumatic fever ... • New murmur, fever
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Systemic Lupus (SLE ... ) General: Fever ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Malar rash 40% - Fever ... involvement 3% SLE-Related ... Lupusreference #SLE ... autoantibodies #signs ... #rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... back pain) • HLA-B27 ... ANA and RF (if clinical ... Arthritis #laboratory #workup ... diagnosis #testing #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
HLH is a critical ... Characteristics: Persistent fever ... • Common Signs ... Persistent high fever ... Fever b.
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... Diagnosis and Workup ... test, ANA (e.g., SLE ... (CVID, WAS), (neurologic ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia - Differential ... genotypes): SS, SC, SE ... bartonella (oroya fever ... Diagnosis #Algorithm #workup ... #hematology #testing
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